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Gene gating Gene gating is a phenomenon by which transcriptionally active genes are brought next to nuclear pore complexes (NPCs) so that nascent transcripts can quickly form mature mRNA associated with export factors. Gene gating was first hypothesised by Günter Blobel in 1985. It has been showed to occur in ''Saccharomyces cerevisiae'', ''Caenorhabditis elegans'', ''Drosophila melanogaster'' as well as mammalian model systems.〔 == Mechanism == Spt-Ada-Gcn5-acetyltransferase (SAGA) is a chromatin remodelling complex responsible for activating the transcription of certain inducible genes. The SAGA complex binds to gene promoters and also interacts with the transcription–export complex 2 (TREX-2 complex). In turn, the TREX-2 complex interacts with the NPC, thus favouring the relocation of actively transcribed genes to the periphery of the cell nucleus.〔 In contrast, the rest of the periphery, i.e. those parts not associated with NPCs, is transcriptionally silent heterochromatin.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Gene gating」の詳細全文を読む
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